Showing posts with label ethnicity. Show all posts
Showing posts with label ethnicity. Show all posts

Thursday, June 23, 2011

What do my Family Finder test results mean?

A slight oversight on my part, I realize that I never did the post that I initially wanted to do for my series on FTDNA's Family Finder test, and that is what information do you get from this test and what does it all mean?

What is the Family Finder test?
Family Finder (FF) is a product from Family Tree DNA that can identify genetic relatives both close and distant up to 5 generations.  The test uses autosomal DNA (Chromosomes 1-22) and the X chromosome to identify regions of your DNA that are "Identical By Descent" (IBD) with other members of the database.  Based on the amount of IBD (as opposed to "Identical By State" (IBS), which is DNA shared between two people that is coincidental) DNA shared between two individuals the algorithms created by FTDNA can determine a relationship range as well as in close genetic relatives, a suggested relationship.


What information do I get from this test?
Personalized website: MyFTDNA
After you order a kit, once it's mailed to you and you swab your cheeks and return the kit to FTDNA, you will get a confirmation email that will identify your Kit # and password.  Then you log into MyFTDNA with your kit # and password and you will be brought to your homepage where once your results come in this will be where everything will be located.

This is what my MyFTDNA homepage currently looks like with my FF results back.

When you first get your kit back you will need to go to where it says "Pending Lab Results" (marked in green). This will tell you what batch # you are in and when your results are expected back.







Once your results are returned the heading (marked in blue) where it says "Family Finder Illumina OmniExpress" will have listed the following tabs (click to take you to that section of this post):


These are the tools that you're going to use to identify your paternal relatives and possibly your biological father.


Matches
Obviously your matches are the most important aspect of this test, but in order to gain the most from them I'm going to explain a few things.

When you first get your results and you click on "Matches" you will be brought to a page that looks like this:


This is a list of your genetic relatives.  However, the default of what is shown is only your close and immediate genetic relatives.  If you do not have any make sure you change the "Relation" bar to include ALL MATCHES.

My close matches take up 2 pages, and all my matches take up 7 pages (I have 12 close matches and 66 total matches).

What you see here is the name of your genetic cousins and the following pieces of information.
Relationship range - this is a range based on FTDNA's algorithms that determines about how close or distant they believe you and this person to be based on the amount of shared DNA.
Suggested relationship - this is again, based on the algorithm devised by FTDNA and is the "most likely" relationship based on DNA. Only close and immediate relatives have a suggested relationship.
Shared cM - cM is "centimorgans" and it's the standard measurement of distance for DNA.  It's actually the recombinant frequency, so if 1cM corresponds to 1 million base pairs, that means that if two markers or SNPs in the genome are 1cM apart, there is a 1% chance of them being separated through crossing-over in a single generation.  So the more shared cM's two people have means they are more likely to be closer related.
Longest block - Again based on cM, while the Shared cM looks at the total amount of shared DNA across the genome, the Longest Block looks at the longest stretch of shared DNA in a row.  Obviously, a long stretch of identical alleles between two individuals suggests that they are very closely related.
Ancestral Surnames - This is a SELF-REPORTED list of surnames that they know are a part of their family (though due to non-parental events - infidelity, secret adoption, donor conception, etc - these are not always accurate).  However,  this will give you an idea as to the potential surnames of your biological father, his possible ethnic groups, and the location(s) that his family may live or have lived.

NOTE ABOUT SUGGESTED RELATIONSHIPS:
It came to my attention after I got my results and started talking to my matches (it never dawned on me before), that the majority of people who order genealogical DNA tests tend to be older (Boomers and up), because they tend to be the ones with the time on their hands to be doing hardcore genealogy research, and have the money to spend on such tests.  However, many donor-conceived adults who are thinking about or have already ordered this test tend to be younger (Boomers and down) than the average genealogist on FTDNA.  So the suggested relationships for those of us who identify as Gen X or Gen Y is going to be skewed.  For example, my #1 match had a relationship range of 1st to 3rd cousin and a suggested relationship of 2nd cousin.  But he is an older gentleman, likely in my grandmother's generation.  So while FTDNA suggests we are 2nd cousins, it is unable to take into account that there is a 2 generation gap between us, so we are probably "closer" cousins than that.  Turns out we are actually 1st cousins 2x removed.  But the algorithms cannot differentiate that.  So just FYI, if your matches are significantly older than you are, it's possible that the most recent common ancestor (MRCA) is not, for example suggested 2nd cousins, your g-grandparents.  In my example, our MRCA is his grandfather, but my gg-grandfather, thus 1st cousins 2x removed.


Chromosome Browser
This is a tool where you can select up to 5 of your matches and see where on the genome you have shared DNA.  This is especially helpful if you want to see perhaps if one of your matches might also be related to another one of your matches.  Though remember, if you all share the same segment of DNA with two different matches it's highly likely that all 3 of you are related, but if there is no shared DNA between the 3 of you it does not suggest that you are NOT all related.


Known Relationships
The KR tab is really sort of a crappy tool.  It's something that honestly should be available for all of your matches, but has been relegated to only those with whom you supposedly can identify with a paper trail. What it does is that for matches that you identify as a "known relationship", you are then able to see what matches you have in common.  Ironically, this feature is available on the free GEDMatch program (but the downfall is that it's much less accurate).


Population Finder

The PF tool is still in beta, but for those of us who are donor-conceived, it might be the best chance we have at determining a general locale that our biological father's ancestry might lie.

As you can see at the left, this is my PF results.  They are as accurate as they could be with the very limited reference samples that FTDNA uses.  Here is a list of their sample set.  As you can see there are only a handful of different ethnic groups for each large population.


The European population set is:
Northern European (Finnish and Russian)
Southeast European (Romanian)
Southern European (Italian, Sardinian, and Tuscan)
Western European (Basque, French, Orcadian, Spanish)

Obviously there are some really huge ethnic groups missing just in Western Europe, not to mention the rest of the continent and all the other population groups!!  What this means is that your PF results are going to take your data and match it to the closest continent(s) and population(s) as possible, but they do not mean that those are your ethnic groups.  Obviously I have no French ancestry, yet PF says I'm 72.4% Western European with French and Orcadian (the Orkney Islands are a part of Scotland).  I'm also a quarter Armenian, yet my Middle Eastern results (27.6%) came up as Iranian (right next door), Adygei (a Caucasus people near Russia - Armenians are also a part of the Caucasus population), and Druze (an eclectic religious sect thats beliefs are a combination of all the Abrahamic religions (Judaism, Christianity, and Islam) found throughout the Levant, mostly Syria, Lebanon, and Israel - not really sure about this one, but same region thus probably similar DNA).

Bottom line, the ethnic groups that I belong to are not population groups that are used in this sample set, so they picked ones that most closely resemble my true ethnic heritage.

My suggestion if you want more accurate ethnic breakdowns, after you get your results email your raw data to Dr. McDonald.  His population sets are much larger and more inclusive and he will give you a much more definite idea as to your ethnic makeup.  Dr. McDonald's analysis of my DNA was pretty much dead on.

Here's what he said about my ancestry:

Most likely fit is 70.5% (± 3.8%) Europe (all Western Europe) and 29.5% (± 3.8%) Mideast (various subcontinents).
The following are possible population sets and their fractions, most likely at the top:
English= 0.677 Armenian= 0.323 
French= 0.768  Iranian= 0.232 
French= 0.726 Georgian= 0.274 
French= 0.696   Adygei= 0.304 
English= 0.660 Georgian= 0.340 
These are in fact exactly what I would expect given what you say. 
Czech comes out an (English or French)/(Armenian or Georgian) mix or an English/Romanian. Thus its no surprise that English-Armenian fits best. 
The Mideast on the chromosomes is very weak indeed, very close to Europe, as befits just a little Armenian, which itself is rather European.
 I'm going to do a post in the near future just on McDonald analysis, so stay tuned for more information about what Principle Component Analysis is and what information you get from Dr. McDonald.


Download Raw Data
Fairly self-explanatory.  You can download your raw data and then use it in some of the programs and tools I talked about last week.

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I will continue this series with more information and advice on how to use your FF results to best of your advantage, including how to best contact matches, how to gain information from matches that don't respond, and more!

Tuesday, June 14, 2011

Jewish donors...a blessing and a curse for ancestral DNA testing

Based on the small sample size of the current members of the brand new Donor Conceived Project at FTDNA [as of 10pm on 6/14/2011: 15 offspring, 1 donor, 12 Americans], it seems the stereotype of all those jewish medical students/residents/doctors being donors could be true.  Almost half (5) of the 12 American offspring have evidence/proof that their biological was, at least ethnically-speaking, Jewish.

The thing that I wanted to bring to light is how this discovery can be both a wealth of information and a black hole of nothing.  And it all boils down to luck.

And here are some reasons why, and some things to consider if you a) believe your biological father was/is Jewish, or b) if you receive results that signify Jewish lineage.

Genetic Bottlenecking
[EDIT 7/2/2011 - see comments for source]


The population bottleneck in Ashkenazi Jewry results from the fact that all of the Ashkenazi Jewish population is descended from a small number of founders who moved to northern France and the Rhineland about 1200 years ago.

A more accurate description of the effect of this bottleneck is not that all AJs are fifth cousins several times over, but rather that all AJs are 10th-30th cousins many, many, many, many, many times over.

In other words, this bottleneck existed long before Hitler. We are all (as eastern European Jews) very closely related. A better name of this bottleneck effect is "founder effect" or founder population.


And since the algorithms used by testing companies like FTDNA look at the amount of shared DNA to establish how closely related two individuals are, with an endogamous population like the Ashkenazi Jews of Eastern Europe, they will falsely predict two individuals of being closer related than they actually are because there is so much shared DNA.

Now FTDNA is trying to correct this by tweaking (or possibly creating a new algorithm??) for individuals who appear to have Ashkenazi ancestry, so anyone who currently has Eastern European Jews as matches may find that some of those matches may disappear and other close matches may be moved to the speculative or more distant categories.

The concern with bottlenecking (and actually dealing with any endogamous population...such as rural America and certain religious groups like the Amish that tend to stay in the same place for generations), is that many of your matches might be much more distantly related than FF suggests, as well as related through multiple avenues.

The Holocaust = No paper trails
Obviously the Holocaust destroyed most, if not all, of the records of European Jews.  With no records and a bunch of recent immigrants that fled death, the likelihood that your matches are going to have extensive family histories and know all their 2nd, 3rd, 4th cousins is rare.  Often they are doing this test to try and find their lost family members who were separated during WWII.  They may or may not be concerned with your plight as a donor offspring, but unless the match is close enough to your biological father that they would be in contact today, they probably are just as clueless as you are!

“Sheyn fergessen”
Surnames.  Many Jews, upon coming to America were either so overwhelmed that, as the Yiddish story goes, the old man, upon arriving at Ellis Island was asked his name, and he responded "sheyn fergessen" (I forgot).  The official at Ellis Island supposedly took that as his name and recorded his name as Sean Fergusson.  Now, whether or not this is a true story is neither here nor there.  The point is that names change.  Especially surnames.  Jews (along with many other Eastern Europeans and Middle Easterners during that time period) often felt the need to change the spelling of their surname, or often change it all-together so that they would be seen more as Americans and not discriminated against.  It's no wonder that some of the most common Jewish names today are Miller and Brown.  This name change, especially a change so recent, could make it nearly impossible to identify your biological father based on the ancestral surnames of your matches, or even on the results of a Y-DNA test!!

But even for the Ashkenazi jews that did not change their names specifically upon coming to America, for most Eastern European jews, surnames as they are seen in Western Europe and America, were a foreign concept to most ethnic groups originating in the Middle East (including my Armenian family).  Patrilineal inheritance of surnames was only something thrust upon them by the governing bodies of the lands where they lived in Europe (Germany, Austria, Russia, etc).  Traditionally most Jews (besides names associated with the ancient priestly castes: Cohen and Levy) were called by their given name, and to differentiate the word "Ben" (son of) and their father's name was added.  When surnames were introduced or mandated, many of the same genetic clan picked up different surnames, often based on the occupation of the head of the household.

So not only might your matches be more distant than FF suggests them to be because they could be your 5th cousin 3 times instead of your 2nd cousin, but that match might not even have any information or surnames that could help you identify your biological father.

Lotsa jews
However...it's not all bad.  The big plus side to discovering or knowing your biological father is/was Jewish (by heritage, not necessarily by religion) is that while most people who sign up for the Family Finder test get dozens of matches, you're likely going to get HUNDREDS of matches!!  Due to a multitude of reasons (reconnecting lost loved ones, missing paper trails, and a a great interest not only in personal genealogy but the genealogy and history of their people), there are more Ashkenazi jews that go through genealogical DNA tests than any other specific ethnic group.

That means you'll have a significantly higher probability of matching with a close or immediate relative of your biological father.

So it's obvious that learning that your  biological father was Jewish provides you with a lot of potential in DNA testing, but also a lot of frustration.  The one thing that I know is that for all my donor-conceived friends who just in the past few months learned their father was Jewish, it gives a sense of identity that was not felt before.

And as I remind myself as go through this testing process, each one of your matches is family.  So the idea of finding your family and learning more at least about your deeper ancestral roots, is something to speak for.

Thursday, May 5, 2011

Quick post on using FamilyFinder DNA

So between advising two DC friends of mine who recently went through with FFDNA tests to help them identify their biological father, and reading on The Genetic Genealogist: Using Autosomal DNA Testing to Identify An Adoptee's Roots, I thought it would be a good time to reiterate this opportunity (albeit a pricey one).

Family Tree DNA's Family Finder Test uses hundreds of thousands of locations across the genome (compared to 15 in a traditional DNA test) and has a large database with which they can identify not just close relatives (parents, siblings, grandparents) but as far out as 5-7th cousins!

This test is especially effective if both you and your mother are tested - though since the cost is close to $300/person, it's not imperative but very helpful.  It's especially helpful if you do not have a very detailed family history of your mother's family, where having her tested will show which matches were maternally inherited (those you share with her), and by process of elimination which matches are paternally inherited and could lead you to your biological father.

So what does this mean for you?  It means if you can identify "close cousins" on your paternal side, it's possible to trace or identify who your biological father is.  Many people who submit their DNA to FFDNA are genealogists, and many have very in-depth family trees.  If you identify a paternal 2nd cousin, this means that individual's father or mother was your biological father's first cousin.  It's likely that that person may have information or even an name of a person that fits the criteria of your biological father (i.e. a medical student at X University from this time to this time).

There are also other tests out there that provide similar information, such as 23andMe - which also provides medical information as well.  I've blogged extensively about the different tests and resources out there...here are just a handful:
Best donor/sibling searching tools
The CODIS Marker SNAFU
Whatcha gonna do with all that junk, all that junk in your...DNA??
PAGE: All About DNA

I hope to save some money and in the near future submit my own DNA for the FamilyFinder Test, which of course I will chronicle here.

Please email me if you have any questions about these tests as I can direct you to people who have gone through with one of these tests and can give you greater insight.

Thursday, March 17, 2011

Kiss Me, I [could be] Irish!

Happy St. Patrick's Day!!  After serious severe weather this winter, and torrential rains and river/lowland flooding the past couple weeks, I was so happy to wake up this morning to beautiful blue skies, sunshine, and what is expected to be 65 degree temperatures!!  Based on the large Irish population here in Northeast Ohio, I might just say this welcomed weather is thanks to the luck of the Irish!

However, St. Patrick's Day tends to hold a sentiment that differs from the usual green beer and corned beef for those conceived from anonymous donors (especially those from the by-gone era of secrecy  and no records).  For most of us, we are deeply interested in the ethnic makeup of our biological father, and therefore half the ethnic makeup of ourselves.

Earlier this week I was talking to Stephanie Blessing on the phone about the newfound knowledge that her biological father was/is Jewish.  For adult offspring like Stephanie, who have absolutely no information, this tiny bit of knowledge gives her not only hope in learning more about him, but also a small sense of self that previously was unknown.

Often donor-conceived adults and adoptees are questioned and wonder about about what ethnic group they supposedly resemble.  It becomes a sort of game, matching personal characteristics with those characteristics that are stereotypically associated with certain ethnic/racial groups, and therefore trying to identify some bit of knowledge about our own identity.

Growing up I often wondered what ethnicity my biological father was, and eventually concluded it was most likely that he was of Anglo-Saxon descent since I still had light colored eyes and my complexion was somewhat fairer than my mother's dark Armenian complexion, and most of all I have LOTS of freckles (and no one else in my family has freckles).  The freckles and the hints of red in my dark hair always made me wonder if my father was Irish.  So I used to joke that I might be Irish so I might as well celebrate St. Patty's Day in full force (mostly in college.......).

Now, when I finally learned my donor number in 2008 and subsequently received minimal information about my biological father, I learned that my hunch that he was Anglo-Saxon was confirmed.  His mother was English or of English descent.  However, there was no ethnic group assigned to his father.  So, I will still stand by my stance on March 17th, "Kiss me, I [could be] Irish!!"